Iron-sulfur cluster signaling: The common thread in fungal iron regulation.
Identifieur interne : 000053 ( Main/Exploration ); précédent : 000052; suivant : 000054Iron-sulfur cluster signaling: The common thread in fungal iron regulation.
Auteurs : Malini Gupta [États-Unis] ; Caryn E. Outten [États-Unis]Source :
- Current opinion in chemical biology [ 1879-0402 ] ; 2020.
Abstract
Iron homeostasis in fungi involves balancing iron uptake and storage with iron utilization to achieve adequate, nontoxic levels of this essential nutrient. Extensive work in the nonpathogenic yeast Saccharomyces cerevisiae and Schizosaccharomyces pombe has uncovered unique iron regulation networks for each organism that control iron metabolism via distinct molecular mechanisms. However, common themes have emerged from these studies. The activities of all fungal iron-sensing transcription factors characterized to date are regulated via iron-sulfur cluster signaling. Furthermore, glutaredoxins often play a key role in relaying the intracellular iron status to these DNA-binding proteins. Recent work with fungal pathogens, including Candida and Aspergillus species and Cryptococcus neoformans, has revealed novel iron regulation mechanisms, yet similar roles for iron-sulfur clusters and glutaredoxins in iron signaling have been confirmed. This review will focus on these recent discoveries regarding iron regulation pathways in both pathogenic and nonpathogenic fungi.
DOI: 10.1016/j.cbpa.2020.02.008
PubMed: 32234663
PubMed Central: PMC7237280
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Outten</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC, USA 29208. Electronic address: outten@sc.edu.</nlm:affiliation><country wicri:rule="url">États-Unis</country></affiliation></author></analytic><series><title level="j">Current opinion in chemical biology</title><idno type="eISSN">1879-0402</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Iron homeostasis in fungi involves balancing iron uptake and storage with iron utilization to achieve adequate, nontoxic levels of this essential nutrient. Extensive work in the nonpathogenic yeast Saccharomyces cerevisiae and Schizosaccharomyces pombe has uncovered unique iron regulation networks for each organism that control iron metabolism via distinct molecular mechanisms. However, common themes have emerged from these studies. The activities of all fungal iron-sensing transcription factors characterized to date are regulated via iron-sulfur cluster signaling. Furthermore, glutaredoxins often play a key role in relaying the intracellular iron status to these DNA-binding proteins. Recent work with fungal pathogens, including Candida and Aspergillus species and Cryptococcus neoformans, has revealed novel iron regulation mechanisms, yet similar roles for iron-sulfur clusters and glutaredoxins in iron signaling have been confirmed. This review will focus on these recent discoveries regarding iron regulation pathways in both pathogenic and nonpathogenic fungi.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">32234663</PMID><DateRevised><Year>2020</Year><Month>07</Month><Day>28</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-0402</ISSN><JournalIssue CitedMedium="Internet"><Volume>55</Volume><PubDate><Year>2020</Year><Month>04</Month></PubDate></JournalIssue><Title>Current opinion in chemical biology</Title><ISOAbbreviation>Curr Opin Chem Biol</ISOAbbreviation></Journal><ArticleTitle>Iron-sulfur cluster signaling: The common thread in fungal iron regulation.</ArticleTitle><Pagination><MedlinePgn>189-201</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1367-5931(20)30024-7</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.cbpa.2020.02.008</ELocationID><Abstract><AbstractText>Iron homeostasis in fungi involves balancing iron uptake and storage with iron utilization to achieve adequate, nontoxic levels of this essential nutrient. Extensive work in the nonpathogenic yeast Saccharomyces cerevisiae and Schizosaccharomyces pombe has uncovered unique iron regulation networks for each organism that control iron metabolism via distinct molecular mechanisms. However, common themes have emerged from these studies. The activities of all fungal iron-sensing transcription factors characterized to date are regulated via iron-sulfur cluster signaling. Furthermore, glutaredoxins often play a key role in relaying the intracellular iron status to these DNA-binding proteins. Recent work with fungal pathogens, including Candida and Aspergillus species and Cryptococcus neoformans, has revealed novel iron regulation mechanisms, yet similar roles for iron-sulfur clusters and glutaredoxins in iron signaling have been confirmed. This review will focus on these recent discoveries regarding iron regulation pathways in both pathogenic and nonpathogenic fungi.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gupta</LastName><ForeName>Malini</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC, USA 29208.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Outten</LastName><ForeName>Caryn E</ForeName><Initials>CE</Initials><AffiliationInfo><Affiliation>Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC, USA 29208. Electronic address: outten@sc.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R35 GM118164</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>03</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Curr Opin Chem Biol</MedlineTA><NlmUniqueID>9811312</NlmUniqueID><ISSNLinking>1367-5931</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Fungal pathogen</Keyword><Keyword MajorTopicYN="Y">Glutaredoxin</Keyword><Keyword MajorTopicYN="Y">Glutathione</Keyword><Keyword MajorTopicYN="Y">Iron homeostasis</Keyword><Keyword MajorTopicYN="Y">Iron–sulfur cluster</Keyword><Keyword MajorTopicYN="Y">Transcriptional regulation</Keyword></KeywordList><CoiStatement>Conflict of interest statement Nothing declared.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>10</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>02</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>02</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="pmc-release"><Year>2021</Year><Month>04</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>4</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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